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An anti-MITF small interfering RNA conjugated to a skin-penetrating peptide in a cream formulation was also successfully used for the treatment of patients with melasma, with an almost complete restoration of skin color on facial lesions after 12 weeks [110], but these agents need optimized topical delivery systems [111]

Our previous study demonstrated that both paclitaxel and vincristine drastically altered the cell mechanical properties of cultured DRG neurons due to excessive tubulin polymerization (paclitaxel) or depolymerization (vincristine)

Methods Enzymol 401:18

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We then explored two human MASLD datasets 38,39 and found that hepatic expression of NR1H3 is increased in individuals with MASLD Activity Scores (NAS) from 1 to 7, compared with those without MASLD (NAS = 0

Al-Zoughbi, W