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Saltiel, A

DOI: 10.1038/cdd.2009.107 56

Ageing Res

Some people process toxins more slowly due to genetic patterns that influence antioxidants, methylation, and detox enzymes

and a family history of Lynch-associated malignant disorders, including endometrial, colorectal, ovarian, gastric, pancreatic, small bowel, urothelial and/or biliary tract cancers, in 2 or more first- or second-degree relatives

Only a small amount of the drug can reach the tumor site after intravenous injection of CDDP, and most of the rest is absorbed by normal cells of the body, such that the body is subjected to serious toxic side effects
