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Thus, while the lactate-TCA cycle-oxidative phosphorylation (OXPHOS) axis is well supported, whether lactate enters mitochondria directly or is first converted to pyruvate in the cytosol remains uncertain, and the preferred route may vary across different tissue types or metabolic conditions [2]

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Pregnancy and breastfeeding call for individualized caution, as with IV nutrients generally

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It is seen across a range of peptides and pharmaceutical compounds that carry ionic or charged components, particularly when those compounds are injected into sensitive or low-fat tissue without adequate buffering

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Aaps J 12:525536

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Introducing exogenous probiotic strains can modify the homeostatic balance of resident gut microbial communities, potentially eliciting unforeseen immunological effects

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pylori by counteracting the initial pro-inflammatory Th1/Th17 response

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