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Nat Rev Endocrinol 10:553562

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Patients enrolled in randomized controlled trials do not represent the inflammatory bowel disease patient population

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Bacterial cells, such as lipopolysaccharides (LPS) and peripheral inflammatory mediators enter the brain via BBB, causing neural inflammation, and subsequently induce neuropathological changes, such as synaptic defects, degeneration, abnormal neurons, and brain chemicals discharge which contribute to the development of depressive disorders

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