amino acid glutathione synthesis REGULATION OF Impaired Glutathione Synthesis in Neurodegeneration

Figures were created with UCSF Chimera and ChimeraX, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases

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Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, et al

Specifically, TMA moieties (such as choline, phosphatidylcholine, and L-carnitine) containing fatty acids are converted to TMA by bacterial TMA lyase via various metabolic pathways (235)

doi: 10.1097/IOP.0000000000001931 163 LiHMaCLiuWHeJLiK

Additionally, in lung cancer, hyperactivation of Nrf2 enables cancer cells to regulate intracellular iron metabolism more effectively, thereby inhibiting iron-dependent lipid peroxidation and evading ferroptosis [10]