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Metabolite Profiling and Enzymatic Activity Assays Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) : Measures methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and homocysteine levels

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Due to the labile nature of the O -glycosidic linkages, fragmentations leading to the loss of sugar moieties are easily induced during MS/MS experiments

Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation
