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Many researchers have focused on investigating the impact of ICB treatment on the interactions between immune cells and cancer cells in the tumor microenvironment (170, 183185), including the tertiary lymphoid structures (186190), as well as the T cell phenotypes in the peripheral circulation (48, 50, 191197)

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SLC7A11 has also been shown to be important in breast cancer stem cell maintenance and correlates with poor prognosis in patients (55, 100)

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doi: 10.1038/nrm.2016.80 88