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It was shown that treatment with dried powdered ginger rhizome improved both allodynia and hyperalgesia by decreasing the inflammatory responses mediated by nitric oxide (NO), prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and interleukin-1 (IL-1) in lipopolysaccharide (LPS)-stimulated macrophages in FMS model mice, indicating that macrophages may contribute to NPP through the release of pro-inflammatory mediators (56)

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doi: 10.3389/fncel.2015.00003

doi: 10.1016/j.chom.2021.01.010 478 ZhangL.WangC.ChenK.ZhongW.XuY.MolnrI.et al

Depression and oxidative stress: results from a meta-analysis of observational studies