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Conclusions Consistent with clinical trials, real-world tirzepatide treatment was associated with greater 6-month weight reduction and more frequent achievement of weight-reduction targets and improvements in select cardiometabolic parameters than semaglutide among adults with obesity without diabetes

Backed by the landmark STEP and SUSTAIN clinical trial programmes, it has been studied for weight management, blood sugar control, appetite regulation, and cardiovascular health

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GLP-1 RA use was consistently associated with improvements in headache frequency, weight reduction, and reduced need for acetazolamide or surgical interventions

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