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Burns 27(7):717722

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A study by Novinscak et al

In this case, the methyl group does not come from methylcobalamin, but from TMG, which turns it into dimethylglycine (DMG)

Summary: Vitamin B12 treatment typically begins producing early haematological responses within 34 days, with neurological symptoms starting to improve within 12 weeks, though complete symptom resolution may require several weeks to months depending on deficiency severity and treatment route