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Since both TcdB and Wnt bind to the FZD-CRD, it is theoretically feasible that the interaction between TcdB and FZDs may directly contribute to the disruption of the colon epithelium by blocking Wnt signaling (Chen et al., 2019)

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Pro-apoptotic proteins such as Bax and Bak promote apoptosis, while anti-apoptotic proteins such as Bcl-2 and Bcl-XL suppress it [131,134]

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