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Patch-clamp experiments demonstrated how melatonin is able to modulate NMDA receptor activity by the drastic attenuation of their currents in neurons located in the spinal cord dorsal horn 93
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Comput Methods Prog Biomed 50:253264 Nauck MA, Petrie JR, Sesti G et al (2016) A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes

The reduced caloric intake subsequently aids in weight loss
