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Sleep and mental health are closely connected: a lack of sleep is strongly associated with anxiety, depression, emotional instability, and stress-related disorders

For example, a person may experience an ischemic muscle spasm while running, due to inadequate blood flow to the leg muscles

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As such, resilient individuals retain cognitive fitness in the face of marked A and tau deposition, whereas frail individuals experience chronic cognitive decline despite lack of AD or other gross neuropathology on autopsy