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Dysregulation of the GSH/GSSG ratio can lead to ER stress, which can be triggered by various pathological conditions [55]

A healthy gut microbiota profile enhances the expression of tight junction proteins (e.g., occludin, Zonula occludens-1 (ZO-1)), reduces intestinal permeability, and limits the systemic translocation of pro-inflammatory mediators such as lipopolysaccharide (LPS), thereby attenuating chronic low-grade inflammation associated with bone loss (Luo et al., 2025)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Rasmussen MK, Mestre H, Nedergaard M
