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1 Introduction Male infertility represents a significant global health burden, contributing to nearly half of all infertility cases among couples ( Conventional semen analysis focuses on sperm concentration, motility, and morphology, yet these parameters do not capture the underlying molecular disturbances that compromise fertilization potential ( 2 Idiopathic male infertility: a clinical and conceptual overview 2.1 Definitions and diagnostic challenges of idiopathic male infertility IMI is broadly defined as the inability to conceive after at least 12 months of unprotected intercourse, in the absence of identifiable female factors, where standard diagnostic evaluations in men fail to reveal a clear etiology ( Diagnostic pathway for male infertility typically includes semen analysis, hormonal profiling, scrotal ultrasonography, karyotyping, and Y-chromosome microdeletion testing ( Importantly, idiopathic infertility is not a true diagnosis but a reflection of the diagnostic gap in current practice

Abu Fanne R, Lidawi G, Maraga E, Moed M, Roguin A, Meisel S-R

WanY ZT

doi: 10.1152/physiolgenomics.00041.2019

The results showed a safe and well-tolerated 188-Rhenium-Imdendrim brachytherapy device for lung cancers ( Significant improvement of cellular uptake along with gene transfection efficacy of PAM-Ap/pMiR-34a NPs in cultured NSCLC cells due to aptamer conjugation was indicated (Wang H

SOD2 binds manganese (Mn) and is located in the mitochondria