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Under copper overload, Cu 2+ specifically interacts with lipoic acid's disulfide bonds, causing pathological effects: Lipoylated protein aggregation: Copper-lipoic acid complexes destabilize PDH and -ketoglutarate dehydrogenase (-KGDH), forcing their oligomerization into insoluble aggregates that block the TCA cycle and collapse ATP synthesis [133]

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characterization of its heterogeneity, impurities, and degradation

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& Abaszadeh, S

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