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Under copper overload, Cu 2+ specifically interacts with lipoic acid's disulfide bonds, causing pathological effects: Lipoylated protein aggregation: Copper-lipoic acid complexes destabilize PDH and -ketoglutarate dehydrogenase (-KGDH), forcing their oligomerization into insoluble aggregates that block the TCA cycle and collapse ATP synthesis [133]

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BPC-157, derived from a protective gastric protein, is known for its potential ability to accelerate wound healing, promote angiogenesis (formation of new blood vessels), and protect the gastrointestinal tract
