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Diabetes and cardiac autonomic neuropathy: clinical manifestations, cardiovascular consequences, diagnosis and treatment

An insufficient aspartate supply leads to mitochondrial metabolic dysfunction, inhibition of mTOR signaling, and reduced expression of cytotoxic molecules such as granzyme B (GZMB) and IFN-, ultimately impairing T-cell cytotoxicity

It should be noted that this study did not enforce exercise on the subjects throughout the supplementation period

Moreover, left undiagnosed, patients of all ages are exposed to the risk of fatal metabolic decompensations [2]

43 The authors of this study concluded that there was insufficient evidence to suggest that vitamin C consumption reduced the risk of pancreatic cancer
