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In the EPB41L4A-AS1-specific knockout astrocyte cell line U251, A 1-42 addition led to significant impairment in A 1-42 clearance and expression of autophagy-related genes (ARGs)

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Hepatocyte transplantation may offer another modality for treatment, but as of now requires immunosuppression to prevent rejection of the transplanted cells and would not necessarily correct complications of portal hypertension as accomplished by orthotopic LT

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