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We review astroglial pathophysiology across the spectrum of human CNS diseases and disorders, including neurotrauma, stroke, neuroinfection, autoimmune attack and epilepsy, as well as neurodevelopmental, neurodegenerative, metabolic and neuropsychiatric disorders

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Significant infiltration of both CD4 + and CD8 + T cells into the SN of PD patients has been described (42), particularly elevated levels of CD8 + T cells (74, 75)