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Overstimulation of metalloproteinases (MMPs), enzymes that break down collagen and elastin

doi: 10.1182/blood-2004-10-3980 169 MasroriP.Van DammeP

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16, Sonthalia, Sidharth, et al

Clinical markers of progression Older age, male sex, higher baseline motor scores and worse baseline cognition have all been linked to worse motor and cognitive outcomes at longitudinal follow-up 141,182,194,195,196 and have been integrated with sleep disorder, presence of depression and various genetic, imaging or CSF biomarkers into clinical predictive scores 182,196

10.1016/j.ijpharm.2006.10.009 78 HalfhideC.EvansH