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Research has shown that alterations in this ratio can significantly impact cellular function, with studies demonstrating that experimental manipulation of NAD+/NADH ratios affects gene expression, enzyme activities, and cellular stress responses

Compr Rev Food Sci F 11:148173 [Google Scholar] Crawford A, Fassett RG, Geraghty DP, Kunde DA, Ball MJ, Robertson IK, Coombes JS (2012) Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease
