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Even without stimulants, high-dose B12 can cause jitteriness, palpitations, or insomnia, worsening anxiety symptoms

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Indeed, recent work with transgenic mice suggests that folate deficiency may predispose heterozygotes for the CBS defect to basal hyperhomocysteinemia (Lentz et al, 2000)

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Possible Side Effects: Mild (Common): Nausea, constipation, dark stools, or stomach upset
