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Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly

Arq Neuropsiquiatr 1999;57:916-20

These features suggest a role in modulating drug activity and reducing side effects and highlight the position of curcumin in the wider context of precision medicine

TCA reduces ferritin heavy chain 1 (FTH1) and ferroptosis-related protein levels, upregulates intracellular iron, reactive oxygen species, and lipid peroxidation levels, thereby exacerbating ferroptosis (Zeng et al., 2025)

For dry or tired skin, it can be used with a relatively rich moisturizer to help support hydration and comfort

Salt stress is commonly caused by high concentrations of sodium ion (Na + ) and chloride ion (Cl ) in the soil solution, and its adverse effects on plants include primary stresses like osmotic stress and ion imbalance, as well as secondary stresses like oxidative stress and metabolic abnormalities (Yang and Guo, 2018a)