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Macrophage-specific p65 knockout (p65 f/f LysM-CreER T2 ) mice on the C57BL/6 background were generated by crossing floxed-p65 littermate (p65 f/f ) mice with LysM-cre mice

The opd genes targeted to periplasm or cell surface of GEMs encodes organophosphorus hydrolase (OPH) which cleaves phosphotriester bond in pesticides for detoxification (Li Q

Our study report genes encoding nucleotide-binding NBS-LRR proteins and TFs, commonly identified in tomato response to pathogens

In addition, methods such as extracellular matrix (ECM) coating and co-culture with non-parenchymal liver cells, such as Kupffer cells and hepatic stellate cells (HSCs), have been used to better replicate the in vivo microenvironment of the liver tissue [27,28,29]

Metabolic plasticity as a resistance mechanism Beyond these biological paradoxes, the clinical failure of metabolic-targeting therapies underscores another key barrier: the extraordinary metabolic adaptability of cancer cells [320]

Similarly, a model of acute pancreatitis displayed activated microglia, indicating crosstalk between the periphery and parenchymal microglial across BBB (Cabral-Frana et al., 2024)