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Studies indicate that in uterine fibroid cells, high concentrations of E can rapidly activate the Ras-Raf-MEK-ERK signaling cascade via a non-genomic pathway, thereby promoting cell proliferation [77,78]

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Ethics declarations Ethics approval This study was performed in line with the principles of the Declaration of Helsinki

The role of zinc sparks requires further investigation, but some evidence suggests that these changes in zinc levels are crucial for subsequent developmental steps and may play a role in zinc-dependent processes regulating oocyte exit from meiosis I

Finally, we elaborate on the meaning and significance of this vast literature as well as its implication for future approaches

The CDs exhibited UCPL when excited at 800 nm, but such UCPL disappeared when a long-pass filter was used for the measurements