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For instance, those with high physical activity may benefit from slightly higher doses, whereas people with pre-existing medical conditions may need to lower the dosage accordingly

however, only time to exhaustion reached statistical significance (Figure 6)

Biol Open 10(1):057042 Cardoso A, Magano S, Marrana F, Andrade JP (2015) D-Galactose high-dose administration failed to induce accelerated aging changes in neurogenesis, anxiety, and spatial memory on young male Wistar rats

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Dwir D., Cabungcal J.-H., Xin L., Giangreco B., Parietti E., Cleusix M., Jenni R., Klauser P., Conus P., Cunod M., et al
The superoxide dismutase 1 ( SOD1 ) and fused in sarcoma ( FUS ) genetic forms of ALS are exceptions as they do not develop TDP-43 aggregates, but instead show cytoplasmic SOD1 and FUS aggregates, respectively [8, 10, 11]
