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Description

This intracellular iron overload is linked to dysregulated expression of key iron-related proteins such as DMT1, TfR1, ferritin, and ferroportin (FPN), which regulate iron influx, storage, and efflux (352, 353, 355, 362)

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Additional Supportive Data ALPINE Trial: Study Design A phase 3b, multicenter, randomized, double-blind, active-controlled study evaluating the efficacy and safety of ARISTADA INITIO (aripiprazole lauroxil) and the ARISTADA (aripiprazole lauroxil) 2-month dose (1064 mg) or paliperidone palmitate monthly 1 The objective of ALPINE (Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness) was to evaluate the efficacy and tolerability of the single-day ARISTADA Initiation Regimen utilizing the ARISTADA 1064 mg 2-month dosing option during the first 4 weeks of treatment in adult patients hospitalized for an acute exacerbation of schizophrenia

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Rigorous human studies are required to determine safety parameters, mechanistic specificity, and potential translational relevance before any clinical applications can be considered