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(2016) observed cirrhosis patients exhibiting over twice the muscle loss rate compared to healthy individuals, with a notable increase in mortality when muscle loss exceeded 3%

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Substitution of PtGSTU19 Tyr 160 by an alanine, cysteine, or phenylalanine residue (PtGSTU19Y160A, PtGSTU19Y160C, and PtGSTU19Y160F variants, respectively) and PtGSTU20 Cys 160 by a tyrosine residue (PtGSTU20C160Y) did not affect (or slightly affected) the affinity for the electrophilic substrate and the turnover number of both enzymes (Supplementary Table S4)