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Strengths Acts via multiple pathways (GLP-1, AMPK, microbiome) Has existing human data showing reductions in fasting glucose, HbA1c, lipids Support receptor expression and islet health Limitations Low absorption and bioavailability Gastrointestinal discomfort is common (diarrhea, cramping)

Not losing weight on a GLP-1

Approximately half of the people currently with multiple sclerosis (MS) are 50years of age, yet guidelines for management of MS in older age are lacking

Maturity-Onset Diabetes of the Young (MODY) is a grouping of monogenic disorders

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- - - A new Oxford meta-analysis (P04.009, EASO 2025) confirms what many clinicians have observed: stopping GLP-1 receptor agonists often leads to rapid and near-complete weight regain within 12 years