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Ananda et al

It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism

Intramuscular (IM) administration of B12 allows for direct delivery, bypassing the digestive system and ensuring efficient absorption, particularly in individuals with malabsorption or gastrointestinal issues

(2001) 280:E2218

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The studies summarized below are predominantly preclinical and should be interpreted accordingly