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In rat and human liver microssomes the electrophilic metabolites of kava, 11,12-dihydroxy-7,8-dihydrokavain- o -quinone and 11,12-dihydroxykavain- o -quinone, were described as glutathione conjugates [44]
This finding is of particular interest, as genomic and proteomic differences in GPx3 have recently been identified in large cohorts of individuals affected with a similar motor neuron disease, ALS 20,21
