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[DOI] [PubMed] [Google Scholar] 12.Lahimer M., Capelle S., Lefranc E., Bosquet D., Kazdar N., Ledu A., Agina M., Cabry R., BenKhalifa M

doi:10.1515/BC.2009.033 Agarwal, Prashant

This inhibition is associated with the regulation of reproductive functions and the promotion of skeletal muscle growth [192, 193]

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Various mechanisms may explain antiproliferative effects of Biliverdin/Bilirubin such as: (1) Overexpression of cdk inhibitor p53 resulting in increased apoptosis of rat SMCs (Liu et al., 2002), (2) Inhibition of cyclin A, D1 and E, YY1 and cdk 2 expression, leading to hypophosphorylation of the retinoblastoma tumor suppressor protein (Rb) and cell cycle arrest (Ollinger et al., 2005), (3) Inhibition of JNK activation (Ollinger et al., 2007), and (4) Modulation of p38 MAPK activation (Ollinger et al., 2005)

Oxidative damage is thought to be a contributing factor for muscle loss, primarily by increasing MPB (Magne et al., 2013)