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SARS-CoV-2 can also infiltrate the CNS by affecting the BBB, e.g., infecting endothelial cells to go through the BBB or triggering inflammatory response to damage BBB (Tana et al., 2022)

Se naturally exists as selenide, elemental selenium, thioselenate (Se 2 O 3 2- ), selenite (SeO 3 2- ), and selenate (SeO 4 2 ), corresponding to the five oxidation states of Se 2- , Se 0 , Se 2+ , Se 4+ , and Se 6+ , respectively ( 4 2- and SeO 3 2- are the dominant Se oxyanions in the soil solution absorbed by plant roots ( 4 2- (+6 oxidation state), whereas those in acidic soils tend to take up SeO 3 2- (+4 oxidation state) ( Therefore, SeO 4 2- becomes more bioavailable in oxic soils, whereas SeO 3 2- dominates anaerobic acidic soils ( 3 2- can be converted to insoluble Se species (Se 0 and Se 2- ), thereby reducing its bioavailability ( 3 - and locks it into the soil profile, causing Se deficiency in crops ( 3 2- can be oxidized to SeO 4 2- ( 4 2- or SeO 3 2- causes a very high leaching rate (Zhai et al., 2019)