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However, functional contributions of GPX3 to autophagy-related ferroptosis have not been fully understood

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Our study confirmed that SFN can be effective against cutaneous inflammation in an IMQ-induced psoriatic mouse model, consistent with previous findings of its therapeutic effects in chronic inflammatory diseases such as inflammatory bowel disease, respiratory diseases, and rheumatoid arthritis [35]

It is instructive that the 2021 EUGOGO guidelines include Se supplementation in the treatment regimen for mild GO, recommending a 6-month treatment with Se preparations for patients with mild GO of short duration to prevent the progression to more severe forms of GO (34)

doi: 10.1111/JTH.15490 26 TownsendLFogartyHDyerAMartin-LoechesIBannanCNadarajanPet al