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There is a lack of long-term effects data, including concerns about abnormal cell growth and the need for ongoing evaluation and monitoring

Thats why vegetarians, vegans, or people with absorption issues (like those with digestive conditions) are more likely to become deficient

quiz 106 Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J: Effective treatment of cobalamin deficiency with oral cobalamin

One study investigating these effects in obese mice discovered that administration of an NNMT blocker reduced insulin serum levels by 50-60% in the subjects

While these immediate effects can be encouraging, they are often short-lived unless supported by regular injections and other complementary treatments or lifestyle changes