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In DOR, the loss of phosphatase and tensin homolog (PTEN) function leads to hyperactivation of PI3K/Akt signaling, resulting in the phosphorylation and inactivation of FOXO3a
[PubMed: 26188606] 11
Role of pharmacogenetics in busulfan/cyclophosphamide conditioning therapy prior to hematopoietic stem cell transplantation
Exogenous Glutathione Enhances Salt Tolerance in Kenaf by Mediating Modulation of Oxidative Stress Response and DNA Methylation
In contrast, no difference in glutathione levels was observed in heart or liver between homozygous and WT mice ( S3A and S3B Fig ), consistent with low expression of Chac1 in these tissues
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