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Transgenic mice overexpressing SNCA A53T displayed progressively deteriorated motor coordination functions in rotarod and pole climbing tests (Figure 1, A and B) and additionally displayed arrhythmic walking patterns (Supplemental Figure 1, AI

These can include gastrointestinal issues, skin rashes, or allergic reactions in rare cases

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This metabolite accumulates within storage vesicles, displacing endogenous norepinephrine and functioning as a false neurotransmitter ( panel 3 )

, 2017a, b)

Redox regulation of FoxO transcription factors