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Additionally, CYP2C19 plays a minor role in metabolism.[ref] While variants that slow the function are common in all of those CYP genes, it is less likely that a variant in any single gene will cause issues with melatonin due to the ubiquity of all three CYP enzymes

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doi: 10.3389/fnbeh.2023.1184897 Received 12 March 2023 Accepted 14 September 2023 Published 28 September 2023 Volume 17 - 2023 Edited by Raffaele d'Isa, San Raffaele Scientific Institute (IRCCS), Italy Reviewed by Sarah Meerts, Carleton College, United States

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If it is a STAT dose or the pharmacy is closed, then this could be considered immediate use

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[DOI] [PubMed] [Google Scholar] 88.Bullitt E

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