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The preclinical safety assessment of BPC-157 presents a toxicological challenge that differs fundamentally from the evaluation of other research peptides.With receptor-targeted compounds GLP-1 receptor agonists, amylin analogs, hGH-derived fragments the toxicology profile is largely predictable from receptor distribution and signaling pharmacology.

In addition to cartilage cell transplants there is also the gentler option of using a high-quality biological matrix as an implant to be injected in the cartilage defect.

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