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Some of the key roles of B12 in your body include: Helping in the normal functioning of the nervous system Playing a vital role in DNA synthesis B12 is among the vitamins needed in the breakdown of amino acids and fatty acids Helps in the creation and maturation of red blood cells (hemoglobin) in the bone marrow Supports the production of digestive enzymes and the delivery of essential nutrients to and from cells Its vital to the development of a fetus in pregnant women Having a deficiency in vitamin B12 can lead to several different symptoms, including fatigue, headaches, pale skin, anemia, vision issues, sores of the mouth/tongue, and even cognitive functioning changes

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Am J Med Genet B Neuropsychiatr Genet 135(1):59 Hatzidimitriou G, McCann UD, Ricaurte GA (1999) Altered serotonin innervation patterns in the forebrain of monkeys treated with ()3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery

215 High expression of NO is a characteristic of UC, and inhibition of the NF-B pathway can also inhibit the expression of IL-6 and iNOS, thereby reducing the content of NO and protecting the intestinal mucosa