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416 Fatty acid uptake and transport by EC is extremely important for many cellular processes, including membrane synthesis, intracellular signaling, ATP production, and post-translational modification of proteins

Indeed, with respect to diabetes, several mitochondrial diseases manifest with diabetic complications such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and maternally inherited diabetes and deafness (MIDD)

By binding to the MT1 and MT2 receptors, melatonin can stimulate the expression and activity of enzymes such as superoxide dismutase (SODwhich reduces the superoxide radical O 2 to H 2 O 2 ), catalase (which decomposes hydrogen peroxide into water and oxygen), and glutathione peroxidase and glutathione reductase (which catalyze the GSSH/GSH reaction that is responsible for activating the antioxidant activity of glutathione, which decomposes hydrogen peroxide)

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You might be thinking to yourself this is the reason I store that layer of fat, and havent been able to lose it with diet and exercise alone

eCollection 2022