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Induction of p21WAF/CIP1 during hyperoxia

References Jones MG, Fabre A, Schneider P, Cinetto F, Sgalla G, Mavrogordato M, Jogai S, Alzetani A, Marshall BG, OReilly KM, Warner JA, Lackie PM, Davies DE, Hansell DM, Nicholson AG, Sinclair I, Brown KK, Richeldi L (2016) Three-dimensional characterization of fibroblast foci in idiopathic pulmonary fibrosis

Pediatrics, 105(6), 12601270

requires FAD as a cofactor FMO3 breaks down trimethylamine and other compounds

doi: 10.1046/j.1471-4159.2001.00205.x 117 CasperDYaparpalviURempelNWernerP

miltiorrhiza (Danshen), significantly inhibits the EMT process in silica-induced pulmonary fibrosis models by suppressing the TGF-1/Smad signaling pathway ( In vitro studies demonstrated that Tan IIA treatment increased nuclear expression of Smad7, inhibited Smad2 and Smad3 phosphorylation by TR1, and reduced the nuclear accumulation of phosphorylated Smad3, thus impeding ECM biosynthesis and myofibroblast differentiation
