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This supports the suggestion that slower escalations of survodutide over a longer treatment period should be explored in future trials to mitigate the occurrence of GI AEs

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it has a risk of abuse, misuse, addiction, physical dependence, and withdrawal reactions

Postgraduate Medicine, 127(8), 818826

Therefore, we can speculate that obesity and increased subcutaneous adipose tissue in both cases may be associated with increased drug half-life and prolonged toleration period

Most patients reach maximum benefit between 12-16 months