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In conclusion, metformin also may have a potential role in the management of cholestatic liver disease due to its antioxidant actions (particularly via glutathione peroxidase enzyme) in an animal model with bile duct ligation-induced liver injury [225]

If genuine tachyphylaxis is confirmed, strategies include dose escalation to the next tier, brief treatment breaks of 2 to 4 weeks to allow receptor resensitization, or switching to alternative GLP-1 agonists like semaglutide to provide different receptor activation patterns

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This cycle ensures a continuous supply of reduced glutathione, amplifying its capacity to combat oxidative stress and maintain cellular health [7]

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Since pregnancy is a temporary state, SI joint usually resolves on its own within four months postpartum