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The strongest data comes from Harshini Neelakantan, Stan Watowich, and colleagues at the University of Texas Medical Branch (UTMB)

Sarcopenia & Muscle Quality : Studied for its ability to improve muscle strength, endurance, and fiber size distribution in aged models

In those patients, addressing the underlying metabolic dysfunction first, through dietary intervention, GLP-1 therapy if indicated, or NAD+ support for cellular energy metabolism, is the clinical priority

Furthermore, similar levels in expression of inflammatory markers such as TLR-signalling members and immune cell markers in muscle of LFD fed Cpt1b m/ mice and LFD fed control mice suggest that depletion of CPT1b indeed keeps inflammatory status in muscle as low as at the LFD level (10% calorie from fat) even in mice fed CHD (25% calorie from fat) or HFD (45% calorie from fat)

This contrasts sharply with full-length human growth hormone, which can impair glucose tolerance and insulin sensitivity, potentially precipitating or worsening diabetes

(10) Streeper RS, et al