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N Engl J Med 382(4):341352 Funding This work was supported by the National Natural Science Foundation of China (Grant number: 82271094), the Medical Joint Fund of Jinan University (Grant numbers:YXJC2022007), the Basic and Applied basic Research Medical Joint Fund of Guangzhou city and Jinan University (Grant numbers: 2023A03J1004) and Science and Technology Projects in Guangzhou (Grant number: 202201020030, 202201020015)

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