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Funding was provided by the American Federation for Aging Research (AFAR), the National Institute on Aging (T32 AG052374), and the USC Manning Endowed Fellowship to J.C.R., a Mork Graduate Fellowship from the USC Viterbi School of Engineering to J.H.J., the USC Viterbi School of Engineering to N.A.G., the NIA (P01AG034906) to P.C., the NIA (R00AG049934), an innovator grant from the Rose Hills foundation, a seed grant the NAVIGAGE foundation, and the Hanson-Thorell Family to B.A.B., Rutherford Discovery Fellowship and a Marsden Fund Fast Start Grant to T.L.M., and the NIA (R01AG052258), Ellison Medical Foundation (EMF), AFAR, and the Hanson-Thorell Family to C.L

A better understanding of the microbiome-immune system interactions will help us develop more targeted, specific antitumor medications in the future

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SLC25A39 depletion inhibits subcutaneous xenograft growth in vivo To evaluate the effect of SLC25A39 on LUAD tumor growth in vivo, we established a xenograft model by subcutaneously injecting 2 10 6 A549 cellseither Cas9 control (Cas9C) or SLC25A39 knockout (koSLC25A39)into the left axilla of nude mice (n = 7 per group)