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At the University of California, San Francisco School of Pharmacy, researchers in the Department of Pharmaceutical Chemistry are tackling that challenge from multiple directions, studying how toxic proteins accumulate in the brain, developing tools to detect disease earlier, and exploring new therapeutic approaches that target the biological processes driving neurodegeneration

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Several lysine residues lie within the sequence near these loops and conceivably would provide the amino groups for cross-linking

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Am J Physiol Endocrinol Metab 2002;282:E326E335

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