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Electron microscopic analysis has shown that 48 h after LPS treatment, the glycocalyx of glomerular endothelial cells and podocytes begins to disappear, and endothelial fenestrations are lost or edematous, such that a gap forms between the podocytes and the basement membrane (15)

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Amino acid starvation results in reduced synthesis of myelin components Cuprizone consumption may alternatively induce demyelination by reducing myelin protein and lipid synthesis which destabilizes the myelin sheath

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