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The presence of neurological complications substantially affects response time

The binding of B12 to IF occurs in the more favorable, less acidic conditions in the small intestine

USADA.org

Originally studied in the 1990s for healing stomach ulcers, researchers discovered it also promotes recovery in other areas of the body
Evolution of nanomedicines for the treatment of autoimmune disease: From vehicles for drug delivery to inducers of bystander immunoregulation

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors